• 0 Posts
  • 11 Comments
Joined 1 year ago
cake
Cake day: June 8th, 2023

help-circle

  • So this is neat. Potentially life changing for some type 2 diabetics, but that depends because some t2 diabetics are not failing to make enough insulin, they’re just no longer sensitive to it at a level that makes it functional for them. I suppose it’s possible that this therapy could cause them to grow enough islet β cells to overcome their lack of sensitivity, but (and I’m a type 1, not a type 2, so maybe my info is incorrect here) that lack of sensitivity can grow with further exposure to insulin making this a stop-gap at best for those cases absent other therapies.

    …and with all of that said, being able to regrow islet β cells has never really been the problem for type 1 diabetes. You can regrow all the islet β cells you’d like and it’s not going to cure the underlying immune disease that has caused your immune system to kill off all of your islet β cells to begin with. Unless you can figure out why t1 diabetes causes one’s own immune system to go psycho killer on their islet β cells, you’ve done nothing to “cure” diabetes. Without being able to suppress that impulse for your immune system to murder your own cells, any ability to replace the islet β cells is going to be temporary at best, and probably a waste on the whole.

    My brother in law is a “cured” type 1 diabetic, by virtue of his having had a kidney replacement and being on immune suppressing drugs for that. Since they were already replacing the kidney and he was going to have to take immune system suppression medications for that, they also just replaced his pancreas at the same time and the suppression of his immune system has allowed the new pancreas to thrive and continue to make insulin. Easy-peasy. The only trade-off is that he is super immunocompromised and can be killed by common colds, so not a great strategy in general.



  • If you’d like to look into it further. the +i flag in chattr is setting an attribute making the file (everything in Linux is a file, so yes this even means directories) immutable. When a file is immutable, it isn’t possible to change the ownership, group, name, or permissions of the file, nor will you be able to write, append, or truncate the file.

    It’s been a while since I’ve used it, but I don’t believe it’s possible to have an immutable directory where you can still modify the contents therein, but I may be misremembering that. It would seem unlikely since adding content to the directory should require that you modify the links for the directory, which shouldn’t be allowable with an immutable object?

    It’s possible that the +a chattr attribute may achieve what you’d prefer. I believe that flag will make it so that files (and again, everything in Linux is a file) can be created and modified, but never deleted. I’ve actually never used this one, but I can foresee how this still may not be ideal for your wishes since updates to games may expect to be able to delete old content which would be thwarted here. 🤷



  • The Nissan Connect stuff doesn’t work anymore for any of the 2016 Leafs, they used a form of cell service that is no longer in operation.

    I swapped a nice Kenwood head unit into my Leaf for a couple hundred dollars. It maintains the backup camera, steering wheel controls, and the built in USB port while offering a larger screen and touch screen controls for Android Auto or Apple Car Play if you want them. It’s awesome and I highly recommend it for anyone who wants a short range commuter car.


  • You or I might, but companies have a constant flow of new middle management who want to make their KPIs this quarter and will shove their own mother in front of an oncoming train to get there. Corporations don’t learn, doubly true for corporations like Apple who have basically captured an audience within their walled garden, the motivation is always all the money now, not some money consistently forever.

    Even when you have a company like Samsung with their exploding battery fiasco. Sure they have protections now in place against designing a new product with bad batteries, but give it some time and they’ll do it again when a middle manager (who wasn’t there the first time) ignores the recommendations of their engineers and the company guidelines so they can save $0.001/phone by using a slightly inferior battery design and net that neat bonus for keeping costs down. It will always happen.





  • If gaming with Nvidia hardware is your primary concern, then maybe Bazzite would suit you. It’s based on Immutable Fedora, with tweaks to give it a SteamOS like experience. It offers Gnome or KDE for the desktop, and supposedly has everything dialed in for gaming. I’ve heard a bunch about it doing great with Nvidia cards and gaming in general, I suspect that you’d be able to do everything else you might need via the desktop it provides, but I have no knowledge of how it handles multiple monitors so maybe therein lies the fatal flaw.