For comparability with each other, this table from Hagezi’s block list on github is a good reference

Honestly the difference mostly comes down to the software you use, from what I can tell. Generally if you use an extension it will be more comprehensive in the blocking, since some sites (like YouTube) serve ads from their own domains.

Also, the Adblock format is what’s used by a lot of the software that blocks ads at a DNS level, at least that consumers will use. Per the table it supports Pi-hole, AdGuard, AdGuard Home, eBlocker, uBlock Origin, Brave (only in aggressive mode), AdNauseam, and Little Snitch Mini, which is pretty comprehensive.

Aside that there’s hosts if you want to do it on a Linux desktop. I don’t recommend that, as you need to manually update the list every so often, though I’m sure it could be automated if you really want to.

Personally I just shoved one of Hagezi’s into AdGuard Home and called it a day. I check it about once a week to see what domains are getting pinged most, and block any suspicious ones.

Edit: No idea why the table condensed that much in the picture, removing it since it’s not really useful if you can’t see the whole table